Ferroptosis Induction is Insufficient to Ensure NK Cell Activation in High-Grade Ovarian Cancer
Ferroptosis induction alone does not consistently enhance NK cell-mediated cytotoxicity in HGOC cells. These findings underscore the heterogeneity of tumor responses and highlight the need for further studies, particularly in <i>in vivo</i> models, to elucidate mechanisms linking ferroptosis to immune recognition and thereby inform therapeutic development.
Authors
- Stefania Scicchitano (ORCID: https://orcid.org/0000-0002-3566-7214)
- Flavia Biamonte (ORCID: https://orcid.org/0000-0003-3248-3863)
- Maria Concetta Faniello (ORCID: https://orcid.org/0000-0001-6938-2754)
- Eleonora Vecchio (ORCID: https://orcid.org/0000-0001-8422-2679)
- Barbara Quaresima (ORCID: https://orcid.org/0000-0003-3462-624X)
- Carmela De Marco (ORCID: https://orcid.org/0000-0002-4893-4246)
- Beatrice Stella
- Antonia Nisticò
- Cinzia Garofalo
Institutions
- Magna Graecia University (IT)
- Azienda Ospedaliero-Universitaria "Renato Dulbecco" (IT)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-02-05
- DOI
- https://doi.org/10.31083/fbl46641
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00