Exploration of a Multidisciplinary Collaborative Management Model in Transarterial Radioembolization with Yttrium-90 Microspheres for Hepatocellular Carcinoma

This is a single-center retrospective observational study. Objective: To evaluate the clinical efficacy and implementation effect of the multidisciplinary collaborative management model in yttrium-90 microsphere radioembolization (Y90-RE) for hepatocellular carcinoma (HCC). Methods: Based on clinical practice, a multidisciplinary team (MDT) consisting of nuclear medicine, interventional vascular surgery, hepatobiliary surgery, radiology, clinical laboratory, nutrition, psychology and nursing teams was established. The responsibilities of each member were clarified, and a full-process standardized protocol covering preoperative assessment, intraoperative collaboration and postoperative management was formulated. Key measures included patient screening and contraindication evaluation, Tc-99m-labeled macroaggregated albumin simulation surgery, Y90 microsphere dose calculation, radiation protection management, nutritional support and psychological intervention. Results: This model standardized Y90-RE and improved treatment efficiency, ensuring the safety and consistency of the treatment process. Through multidisciplinary collaboration, comprehensive perioperative management of patients was effectively achieved, the risk of complications was reduced, and patients’ treatment compliance and rehabilitation quality were improved. Conclusion: The multidisciplinary collaborative management model is crucial to ensuring the perioperative safety and efficacy of Y90-RE for HCC patients and helps improve the standardized application level of this treatment. In the future, the diagnosis and treatment process will be further optimized through data accumulation, and the model will be extended to out-of-hospital continuous management, which also provides a promotable practical paradigm for the individualized and systematic treatment of complex tumor diseases.