HLA variation analysis and autoantigen epitope prediction in idiopathic inflammatory myopathies
In the anti-Mi2 subgroup, we identified novel HLA alleles, amino acid variants and immunogenic epitopes, supporting a role for HLA-restricted antigen presentation in disease pathogenesis and indicating candidate targets for antigen-specific immunotherapy. However, the HLA/epitope findings related to anti-Mi2 are exploratory due to limited power, and require confirmation in larger cohorts together with experimental validation.
Authors
- R. Bhatia
- Danveer Bhadu (ORCID: https://orcid.org/0000-0002-3762-9780)
- Rakesh Kumar Deepak (ORCID: https://orcid.org/0000-0002-8355-3019)
- Aishwarya Dhall
- Vaishali S. Suri (ORCID: https://orcid.org/0000-0001-6485-8194)
- Bandana Jassal
- MC Sharma
- U Kumar
- GS Chopra
- M Kumar
- Venugopalan Yamuna Vishnu
Institutions
- Galgotias University (IN)
- Immungenetics (Germany) (DE)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1093/rheumatology/keag049
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00