Clinical performance of an IGF1 LC-MS/MS assay and associated normative dataset in routine endocrinology
Our LC-MS/MS IGF1 assay integrated with its own population-based normative dataset demonstrated superior alignment with clinical assessment compared with LBA results. In our setting, this method provides a clinically reliable benchmark for IGF1 interpretation and may serve as a reference for IGF1 harmonization and broader adoption of the Lifelines normative dataset in routine endocrinology.
Authors
- Eef G.W.M. Lentjes (ORCID: https://orcid.org/0000-0003-4055-2291)
- Gianni Bocca (ORCID: https://orcid.org/0000-0002-2665-8738)
- van Beek Ap
- Mark R Postma (ORCID: https://orcid.org/0000-0003-3203-8209)
- Dylan Kelly
- Ido P. Kema
- Martijn van Faassen
- Michel J Vos
- Lisanne Habich-Reijntjes
- Anneke Muller Kobold
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1093/ejendo/lvag040
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00