Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

KD01 exerts potent tBID-mediated mitochondrial oncolytic activity against glioma cells. When used as a priming strategy, transient vascular normalization induced by bevacizumab enhanced the intratumoral efficacy of KD01 in an orthotopic glioma model while maintaining a favorable safety profile. These findings support a simple, sequence-dependent combination approach integrating anti-VEGF therapy with oncolytic virotherapy for the treatment of malignant gliomas.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2026-02-13
DOI
https://doi.org/10.31083/fbl48473
Primary Topic
Virus-based gene therapy research
Type
article
Field-Weighted Citation Impact
0.00

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article

Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

Y. T. Gu, F Ye, Baiwei Zhang, Zuodong Yuan et al.
Frontiers in Bioscience-Landmark
Virus-based gene therapy research
article

Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

Y. T. Gu, F Ye, Baiwei Zhang, Zuodong Yuan, Chansachak Chea
article en

Abstract

KD01 exerts potent tBID-mediated mitochondrial oncolytic activity against glioma cells. When used as a priming strategy, transient vascular normalization induced by bevacizumab enhanced the intratumoral efficacy of KD01 in an orthotopic glioma model while maintaining a favorable safety profile. These findings support a simple, sequence-dependent combination approach integrating anti-VEGF therapy with oncolytic virotherapy for the treatment of malignant gliomas.

Frontiers in Bioscience-LandmarkVol. 31(2)
Tongji Hospital (CN), Huazhong University of Science and Technology (CN)
Huazhong University of Science and Technology, Tongji University, Tongji Medical College, Huazhong University of Science and Technology
Good health and well-being
Openalex Percentile: Top 38%
Virus-based gene therapy research
DOIOpen Access PDFOpenAlex
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