Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis
BP is an effective adjunct to ATO therapy, counteracting gut dysbiosis, intestinal damage, and the immune microenvironment while synergistically improving antileukemic efficacy. Targeting the gut-leukemia axis with BP represents a promising strategy for improving the precision and safety of APL treatment.
Authors
- Liwang Lin
- Yanqiu Zhao (ORCID: https://orcid.org/0009-0009-8085-2302)
- Longyu Li (ORCID: https://orcid.org/0009-0002-6572-3544)
- Wenlei Zhang
- Zengliang Gao
- Xianjun Ni (ORCID: https://orcid.org/0009-0008-1326-2700)
- Zhibo Guo
- Lijuan Yue
- Shengjin Fan
- Xin Hai
- Qi Li
- Yutong Liu
- Dan Guo
- Shiao Ren
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-02-05
- DOI
- https://doi.org/10.31083/fbl48584
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province