Triaminoguanidine-Isothiocyanate Reactions: Synthesis and Characterization Studies

Heterocyclic compounds are found in natural products, drugs, pigments, vitamins, coenzymes and many biological processes. They have important roles in technological applications as well as in pharmaceutical, biological and medical uses. Guanidines are one of the most versatile functional groups in chemistry and containing this system have found application in a variety of biological activities. Guanidine is described as an organo-superbase with basicity of amine groups relative to conjugate acids and resonance stabilization, which is typically critical to its biological effects [1]. Aminoguanidine (AMG), also known as imidamide, guanylhydrazine and pimagedine, was obtained in 1892.