Renal fibrosis prevention with perinatal stem cells: Biomarkers of kidney tissue damage

Background and Aim. Acute kidney injury (AKI) is a potentially reversible process, but its episodes can lead to chronic kidney disease (CKD) - in about 15% of patients (1, 2, 3, 4). There is currently no effective or timely treatment to stop the progression of the disease (5, 6). Human placenta-derived mesenchymal stromal cells (hpMSCs) are a promising new remedy in regenerative medicine and pharmacology. HpMSCs may be a promising source for cells therapy due to their extensive sources and low immunogenicity (7). Our aim was to compare evolution of histological biomarkers during AKI emergence and conversion towards CKD. [...].