Plant-based oromucosal spray: Formulation and quality evaluation

Introduction. The problem of infectious and inflammatory diseases of the oral cavity is one of the most urgent and widespread in dental practice. One of the most popular forms of local drug administration for these pathologies are oromucosal sprays. This dosage form has several advantages: increased pharmacological activity due to the dispersion of the medicinal substance, a high degree of exposure to mouth mucous membranes, rapid absorption, the exclusion of the negative effect of the digestive tract on the active substance, tightness, dosage accuracy, painlessness,convenience, and speed of use, as well as simplicity and economy of production. According to data in the literature, natural products and essential oils are often used in dental practice. A combination of CO2 extract of cloves and essential oils of lavender and grapefruit was chosen as the objects of this study. The expected outcome of this combination is the ability to effectively contribute to the prevention and treatment of infectious and inflammatory processes, namely, to inhibit the activity of pathogenic microflora in the oral cavity, provide anti-inflammatory and analgesic effects, eliminate unpleasant odours, stimulate reparative processes, andepithelize affected areas of the periodontium and mucous membrane.