Optimal Duration of Antibiotic Holiday Before Reimplantation in Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection: Systematic Review and Meta-analysis

With the number available, the findings identified no notable difference in treatment failure rates with short (<2 weeks) or extended (≥2 weeks) antibiotic holiday duration between the two stages. However, the evidence is limited by substantial heterogeneity among studies, and further studies are necessary to appropriately address this topic.