<scp>3D</scp> virtual histology demonstrates tumour connectivity in spread through air spaces ( <scp>STAS</scp> ) of non‐small cell lung cancer

These findings indicate that most STAS types are clusters of cells connected to the main tumour mass. 3D X-ray virtual histological investigation helps to understand the morphological composition and spatial evolution of the tumour, as well as the presence of a tumour larger than that visible in the histological slide. From a radiological and surgical perspective, these findings may influence the assessment of the extent of parenchymal involvement and help guide the surgical approach.

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Publication Details

Journal
Histopathology
Published
2026-02-26
DOI
https://doi.org/10.1111/his.70130
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

3D virtual histology demonstrates tumour connectivity in spread through air spaces ( STAS ) of non‐small cell lung cancer

Elisa Baratella, Cristina Bottin, Maria Assunta Cova, F. Martellani et al.
Histopathology
Lung Cancer Diagnosis and Treatment
article

3D virtual histology demonstrates tumour connectivity in spread through air spaces ( STAS ) of non‐small cell lung cancer

Elisa Baratella, Cristina Bottin, Maria Assunta Cova, F. Martellani, Stefano Lovadina, Giulia Saccomano, Francesco Brun
article en

Abstract

These findings indicate that most STAS types are clusters of cells connected to the main tumour mass. 3D X-ray virtual histological investigation helps to understand the morphological composition and spatial evolution of the tumour, as well as the presence of a tumour larger than that visible in the histological slide. From a radiological and surgical perspective, these findings may influence the assessment of the extent of parenchymal involvement and help guide the surgical approach.

Histopathology
University of Trieste (IT), Elettra-Sincrotrone Trieste S.C.p.A. (IT), Ospedale di Cattinara (IT)
Good health and well-being
Openalex Percentile: Top 40%
Lung Cancer Diagnosis and Treatment
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