Bioactive oxadiazolo-benzodiazepines: synthesis, α amylase inhibition, antioxidant activity, molecular docking and DFT calculation
Both diastereoisomers <b>3</b> and <b>4</b> demonstrated superior activity compared to standard drugs. Compound <b>3</b> showed potent α-amylase inhibition IC<sub>50</sub> = 22.78 µM) compared to Acarbose IC<sub>50</sub> = 123 µM). For antioxidant activity, compounds <b>4</b> and <b>3</b> exhibited strong DPPH scavenging IC<sub>50</sub> = 68.16 and 79.50 μM, respectively), outperforming ascorbic acid. Docking studies confirmed favorable binding interactions within the active sites of target enzymes. The synthesized oxadiazolo-benzodiazepines represent promising multifunctional antidiabetic and antioxidant candidates, warranting further pharmacological investigation.
Authors
- My El Abbes Faouzi
- Ismail Hdoufane (ORCID: https://orcid.org/0000-0002-1435-5131)
- Marouane Ait Lahcen
- Nouhaila Ait Lahcen
- A. Baouid (ORCID: https://orcid.org/0000-0002-2434-9181)
- Mohamed Maatallah (ORCID: https://orcid.org/0000-0001-7921-8587)
- Samir Hmaimou
- Mohamed Adardour (ORCID: https://orcid.org/0000-0002-4813-0694)
- Driss Cherqaoui (ORCID: https://orcid.org/0000-0003-1327-306X)
- Driss Fadili (ORCID: https://orcid.org/0000-0002-5079-5484)
- Wissal Karfi
- Elena Zaballos-García
Institutions
- Cadi Ayyad University (MA)
- Mohammed V University (MA)
- Universitat de València (ES)
- Université Mohammed VI Polytechnique (MA)
- Instituto Superior da Maia (PT)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1080/17568919.2026.2636823
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00