Identification of <scp> <i>NTRK3</i> </scp> fusions in plaque‐like <scp>CD34</scp> ‐positive dermal fibroma

NTRK3 gene fusions occur in a subset of plaque-like CD34-positive dermal fibromas, providing additional molecular insight into this rare superficial spindle cell lesion. Together with emerging literature, these findings support a role for recurrent kinase gene rearrangements in a subset of CD34-positive plaque-like superficial spindle cell tumours, while underscoring the continued importance of clinicopathologic correlation in defining this evolving spectrum.

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Publication Details

Journal
Histopathology
Published
2026-02-26
DOI
https://doi.org/10.1111/his.70120
Primary Topic
Cancer and Skin Lesions
Type
article
Field-Weighted Citation Impact
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article

Identification of NTRK3 fusions in plaque‐like CD34 ‐positive dermal fibroma

Gauri Panse, Jeffrey M Cloutier, Iwei Yeh, Michael Lee
Histopathology
Cancer and Skin Lesions
article

Identification of NTRK3 fusions in plaque‐like CD34 ‐positive dermal fibroma

Gauri Panse, Jeffrey M Cloutier, Iwei Yeh, Michael Lee
article en

Abstract

NTRK3 gene fusions occur in a subset of plaque-like CD34-positive dermal fibromas, providing additional molecular insight into this rare superficial spindle cell lesion. Together with emerging literature, these findings support a role for recurrent kinase gene rearrangements in a subset of CD34-positive plaque-like superficial spindle cell tumours, while underscoring the continued importance of clinicopathologic correlation in defining this evolving spectrum.

Histopathology
Dartmouth–Hitchcock Medical Center (US), University of California, San Francisco (US), Yale University (US), New York University (US)
Openalex Percentile: Top 40%
Cancer and Skin Lesions
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