Dysregulated Klotho and FGF23 signalling aggravates vascular remodelling in age-related pulmonary hypertension
Our findings identify accumulation of FGF23 as novel mechanism of pulmonary vascular remodeling in PAH. Targeting dysregulated Klotho/FGF23 signaling may present a promising therapeutic strategy in elderly patients.
Authors
- Kristina Norman (ORCID: https://orcid.org/0000-0003-2029-9102)
- G Kovacs
- Vasile Foris (ORCID: https://orcid.org/0000-0002-8863-0298)
- Christiane Ott (ORCID: https://orcid.org/0000-0002-3199-0655)
- Laura Michalick (ORCID: https://orcid.org/0000-0002-3959-5828)
- Willem Bintig
- Teresa C. Funk-Hilsdorf
- Philip Solymosi
- Jana Grune (ORCID: https://orcid.org/0000-0001-6209-7416)
- Catrin Herpich (ORCID: https://orcid.org/0000-0003-3059-1705)
- Jakob Voelkl (ORCID: https://orcid.org/0000-0002-6318-5087)
- Paul-Lennard Perret
- Jonathan H. Kim (ORCID: https://orcid.org/0000-0002-8668-8074)
- Wolfgang M. Kuebler
- Petra Knaus
- Ursula Müller-Werdan
- Annika Winkler
- Makoto Kuro-O
- Erik Asmus
- Tilman Grune
- Szandor Simmons
Institutions
- Johannes Kepler University of Linz (AT)
- Brigham and Women's Hospital (US)
- St. Michael's Hospital (CA)
- Jichi Medical University (JP)
- University of Potsdam (DE)
- University of Toronto (CA)
- Medical University of Graz (AT)
- Humboldt-Universität zu Berlin (DE)
- Ludwig Boltzmann Institute for Lung Vascular Research (AT)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- German Institute of Human Nutrition (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1093/cvr/cvag048
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00