DNA-and BSA-binding properties of dichloro(1-methallyl-3-arylmethyl-5,6-dimethylbenzimidazolin-2-ylidene)pyridine palladium(II) complexes
According to the experimental method, complex <b>2a</b> exhibited the strongest binding constant against DNA (1.84 × 10<sup>4</sup> M<sup>-1</sup>), while complex <b>2c</b> demonstrated the highest BSA binding constant (2.83 × 10<sup>4</sup> M<sup>-1</sup>). Subsequent to molecular docking, and consistent with experimental findings, it was determined that all molecules exhibited interaction with the same DNA and BSA residues. Complex <b>2a</b> demonstrated the strongest binding affinity against DNA, while complex <b>2c</b> manifested the most robust interaction with a binding value of -8.09 kcal/mol. A thorough evaluation of the drug-likeness properties of the palladium(II) complexes was conducted using the SwissADME web tool.
Authors
- Neslihan Şahin (ORCID: https://orcid.org/0000-0003-1498-4170)
- Elvan Üstün
- David Sémeril
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
- Malatya Turgut Özal Üniversitesi (TR)
- Ordu University (TR)
- Turgut Özal University (TR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1080/17568919.2026.2636820
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00