Safety and Effectiveness of Eculizumab in Patients With Refractory Ocular or Ocular‐Predominant Myasthenia Gravis: A Case Series

In patients with refractory ocular or ocular-predominant MG, eculizumab had a rapid onset of therapeutic effect that was sustained after 12 weeks, regardless of the antibody titer. The favorable safety profile supports its use in treatment-resistant cases of refractory OMG or ocular-predominant MG. Larger randomized controlled trials are needed to establish the long-term effectiveness and optimize treatment protocols.

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Publication Details

Journal
Muscle & Nerve
Published
2026-02-25
DOI
https://doi.org/10.1002/mus.70183
Primary Topic
Myasthenia Gravis and Thymoma
Type
article
Field-Weighted Citation Impact
0.00
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article

Safety and Effectiveness of Eculizumab in Patients With Refractory Ocular or Ocular‐Predominant Myasthenia Gravis: A Case Series

Qi Niu, Shiyu Shi, Pan You, Xi Cheng et al.
Muscle & Nerve
Myasthenia Gravis and Thymoma
article

Safety and Effectiveness of Eculizumab in Patients With Refractory Ocular or Ocular‐Predominant Myasthenia Gravis: A Case Series

Qi Niu, Shiyu Shi, Pan You, Xi Cheng, Yu Zhang, Wenping Yang
article en

Abstract

In patients with refractory ocular or ocular-predominant MG, eculizumab had a rapid onset of therapeutic effect that was sustained after 12 weeks, regardless of the antibody titer. The favorable safety profile supports its use in treatment-resistant cases of refractory OMG or ocular-predominant MG. Larger randomized controlled trials are needed to establish the long-term effectiveness and optimize treatment protocols.

Muscle & Nerve
Nanjing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 45%
Myasthenia Gravis and Thymoma
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