MSC-small extracellular vesicles alleviated Th2-airway inflammation by regulating the metabolism of DCs in mice
MSC-sEV are able to alter the metabolic state of DCs, favoring DCs to maintain OXPHOS (oxidative phosphorylation) rather than glycolysis, thereby reducing DCs-initiated inflammatory responses and attenuating Th2 lung inflammation, suggesting MSC-sEV can be a potential clinical therapy for airway inflammation.
Authors
- Chang Li (ORCID: https://orcid.org/0000-0002-3267-1859)
- Lifen Wen (ORCID: https://orcid.org/0000-0003-0229-7306)
- Qi‐Jian Sun (ORCID: https://orcid.org/0000-0003-3624-9839)
- Zicong Wu (ORCID: https://orcid.org/0000-0002-8472-3016)
- Yingchun Xie (ORCID: https://orcid.org/0000-0002-3166-303X)
- Qing-Ling Fu
- Bi-Xin He
- Tian Tian
- Long-Xin Huang
- Xiao-Qing Liu
- Zhi-Rou Zhou
- Zhi-Bin Xu
Institutions
- Sun Yat-sen University (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1093/stcltm/szag010
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00