Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy
Together, these findings provide critical insights into the functional differences and origin of macrophage subpopulations in human atherosclerosis and show their clinical significance and risk prediction value in relation to future cardiovascular events.
Authors
- Johan Kuiper (ORCID: https://orcid.org/0000-0001-5834-690X)
- Moritz Reif
- Ilze Bot
- Dominique PV de Kleijn
- A. Wezel
- H.J. Smeets (ORCID: https://orcid.org/0000-0002-4370-1611)
- Barend Mol
- MAC Depuydt
- Pieter Goossens (ORCID: https://orcid.org/0000-0002-7269-6372)
- Michal Mokry (ORCID: https://orcid.org/0000-0002-7719-6668)
- Jiangming Sun (ORCID: https://orcid.org/0000-0001-6814-1297)
- Erik S. G. Stroes
- Gemma Bel-Bordes (ORCID: https://orcid.org/0009-0006-1995-8077)
- Jeffrey Kroon (ORCID: https://orcid.org/0000-0001-9983-6614)
- Annette E. Neele (ORCID: https://orcid.org/0000-0001-9029-3991)
- Bram Slütter (ORCID: https://orcid.org/0000-0003-3996-0503)
- Yayuan Zhu (ORCID: https://orcid.org/0000-0003-1349-3038)
- Jaap D. van Buul
- Panos Barlampas
- Gert J. de Borst
- Gerard Pasterkamp
- Guillermo R Griffith
- Cindy van Roomen
- Rosalie W M Kempkes
- Koen H M Prange
- Maaike J M de Jong
- Max L B Grönloh
- Menno P J de Winther
Institutions
- Leiden University (NL)
- Lund University (SE)
- Utrecht University (NL)
- Heidelberg University (DE)
- Maastricht University Medical Centre (NL)
- Angiogenesis Foundation (US)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- Cardiovascular Institute Hospital (JP)
- Maastricht University (NL)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Medisch Centrum Haaglanden (NL)
- Amsterdam Neuroscience (NL)
- Centre for Human Drug Research (NL)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1093/eurheartj/ehag117
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00