Transcriptome‐Based Evaluation of Hydrogen Gas Effects for Preventing <scp>UVA</scp> ‐Induced Photoaging Using an Artificial Skin Model
This study demonstrated that photoaging-related transcriptomic changes were detectable in artificial skin under a relatively low UVA dose (7 J/cm<sup>2</sup>/day; total 21 J/cm<sup>2</sup>) with minimal histological alterations. Furthermore, hydrogen may have a protective effect against UVA-induced cellular stress and senescence, via diffusion through the skin surface, suggesting its potential effectiveness in preventing photoaging. This study provides preliminary evidence that may contribute to the development of future translational research on the utility of molecular hydrogen in UVA-induced photoaging.
Authors
- Erika Takemasa
- T. Kiyoi
- Masaki Mogi (ORCID: https://orcid.org/0000-0002-0275-9198)
- Kentaro Uchida
- Shuang Liu
- Naohito Hato
Institutions
- Panasonic (Japan) (JP)
- Kanazawa Medical University (JP)
- Ehime University (JP)
Publication Details
- Journal
- Geriatrics and gerontology international/Geriatrics & gerontology international
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1111/ggi.70401
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00