Association of Coxsackievirus infection with serum Interleukin-12 levels in Iraqi patients with Dilated Cardiomyopathy

<ns7:p> Background Dilated cardiomyopathy (DCM) is a condition characterized by the dilation and dysfunction of the left ventricle, leading to heart failure. This study investigates the relationship between dilated cardiomyopathy and factors such as lipid levels, interleukin-12 (IL-12) levels, troponin levels, and coxsackievirus antibodies. Methods This study involved 60 patients diagnosed with dilated cardiomyopathy and 30 healthy controls. We used a BioSystems kit to measure lipid profiles and a fully automated c111 analyzer (Germany) to quantify troponin levels. We used ELISA to evaluate IL-12 levels and antibodies (IgG and IgM) to Coxsackievirus. We used SPSS for data analysis, with statistically significant defined as p≤0.05 <ns7:italic>.</ns7:italic> Results Patients with dilated cardiomyopathy showed a significant difference in lipid levels compared to the control group, while HDL levels showed no statistically significant difference. In addition, troponin levels were significantly elevated in patients with dilated cardiomyopathy. IL-12 levels were elevated by 1.27-fold in individuals with dilated cardiomyopathy suggests a reasonable diagnostic accuracy. Antibody levels for Coxsackievirus (IgG and IgM) were markedly elevated in dilated cardiomyopathy, with a positive test in both IgG t and IgM, while no positive controls were observed for either antibody.in addition This study evaluated the associations between IL-12, IgM, and IgG. The results showing nonsignificant correlation between IL-12 and IgM and IL-12 and IgG. Conclusion Elevated IL-12 levels and coxsackievirus-positive antibodies in dilated cardiomyopathy patients suggest a possible immune link. However, no statistically significant relationship has been found between IL-12 and coxsackie virus antibodies. </ns7:p>