<i>Enterobacter hormaechei</i> co-harbouring <i>bla</i> KPC-2, <i>bla</i> VIM-24, and <i>bla</i> NDM-1: the rise of the ‘unholy trinity’

Although the emergence of triple-carbapenemase producers has been reported, it remains rare. However, sentinel isolates as the one described here (KPC-VIM-NDM) are extremely worrisome since dissemination of multiple carbapenemases could occur via conjugative plasmids in addition to horizontal gene transmission via mobile genetic elements. Considering that Colombia has long been considered a KPC-endemic country, the findings described here call for a thorough epidemiological surveillance to assess the real frequency of Enterobacterales carrying multiple carbapenemases.