Blood–Brain Barrier‐Permeable <scp>siRNA</scp> Nanodrugs With Dual‐Gene Knockdown for Alzheimer's Disease Therapy
In this study, we successfully constructed a brain-targeted siRNA nanocarrier delivery system for double-gene knockdown. This system can efficiently overcome the obstacle of the BBB, markedly alleviating cognitive and memory deficits in AD mice. It paves the way for novel strategies in the clinical treatment of AD and is expected to bring new breakthroughs and changes to the conquest of this disease.
Authors
- Guangwei He (ORCID: https://orcid.org/0000-0002-6580-5219)
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Junli Zhang (ORCID: https://orcid.org/0000-0001-6083-5112)
- Lifang Yin
- Yungen Xu
- Feng Su
- Ling Cheng
- Shengnan Lu
- Ying Li
- Yaoyao Zhang
- Yu Zhang
Institutions
- China Pharmaceutical University (CN)
- Anhui Medical University (CN)
- Hefei Institute of Technology Innovation (CN)
Publication Details
- Journal
- Clinical and Experimental Pharmacology and Physiology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1111/1440-1681.70108
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00