Identification of Key Genes Associated With Epithelial Barrier Dysfunction by Comprehensive Analysis and Experimental Validation
Our findings confirm that targeting CDC7 and TCN1 facilitates the improvement of barrier function in airway epithelial cells, epidermal keratinocytes, and intestinal epithelial cells in vitro, thereby providing promising therapeutic targets for diseases characterized by epithelial barrier dysfunction.
Authors
- Shixiu Liang (ORCID: https://orcid.org/0000-0001-9162-1993)
- Meihua Dong
- Z. P. Yao
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Siqi Wang (ORCID: https://orcid.org/0000-0002-5514-6336)
- Yingjun Chen (ORCID: https://orcid.org/0000-0002-4784-8282)
- Xiaodi Zhu
- Di Wu (ORCID: https://orcid.org/0009-0009-7526-8961)
- Sitong Lin
- Shiting Yi
- Yanwen Li
Institutions
- Foshan University (CN)
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Allergy
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1111/all.70275
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00