Negative Regulator of Interferon Response Promotes Toll-like Receptor 3-induced Interleukin 6 in Rheumatoid Synoviocyte
<i>NRIR</i> is induced by TLR3 signaling in RFLS. IFN-b and NF-kB are involved in <i>NRIR</i> induction <i>via</i> TLR3 signaling. <i>NRIR</i> is at least partially implicated in TLR3-mediated IL-6 expression in RFLS. <i>NRIR</i> may play a role in TLR3/IL-6-mediated inflammatory reactions in RFLS and may be a potential target for new therapeutic strategies against RA.
Authors
- Kairo Wada
- Kazuhiko Seya (ORCID: https://orcid.org/0000-0001-5866-7148)
- Kazuki Oishi (ORCID: https://orcid.org/0000-0002-2254-6472)
- Eiji Sasaki (ORCID: https://orcid.org/0000-0002-4859-8473)
- Tatsuro Saruga
- HIKARU KRISTI ISHIBASHI
- KANICHIRO WADA
- YASUYUKI ISHIBASHI
- MAYUKI TACHIZAKI
- TADAATSU IMAIZUMI
Institutions
- Hirosaki University (JP)
Publication Details
- Journal
- In Vivo
- Published
- 2026-02-27
- DOI
- https://doi.org/10.21873/invivo.14242
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00