Clinical Significance of Microembolic Signal Detection in Acute Ischemic Stroke: Insights Into Ongoing Cerebral Embolization and Occult Etiologies
MES were detected in one-sixth of anterior circulation AIS patients, but were absent in lacunar stroke. Their presence was associated with multiple-territory infarcts, newly detected atrial fibrillation, and cancer-related stroke. MES counts correlated with D-dimer levels, supporting their role as markers of ongoing cerebral embolization and underlying prothrombotic state, with potential utility in revealing occult embolic mechanisms.
Authors
- Anastasios Bonakis (ORCID: https://orcid.org/0000-0003-0509-5910)
- Stella Fanouraki (ORCID: https://orcid.org/0009-0003-3496-7543)
- Anna Keramida (ORCID: https://orcid.org/0000-0002-8218-950X)
- Lina Palaiodimou
- Theodore Karapanayiotides
- Apostolos Safouris
- Georgios Tsivgoulis
- Andrei V Alexandrov
- Branko Malojčić
- Maria Chondrogianni
- Georgia Papagiannopoulou
- Angeliki-Erato Sterpi
- Eleni Bakola
- Aikaterini Theodorou
- João Sargento-Freitas
Institutions
- University of Padua (IT)
- University Hospital Centre Zagreb (HR)
- National and Kapodistrian University of Athens (GR)
- AHEPA University Hospital (GR)
- Banner Health (US)
- Banner - University Medical Center Phoenix (US)
- Metropolitan Hospital (GR)
- University of Coimbra (PT)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1111/ene.70550
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00