Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis
Our findings suggest that rapamycin reduces amyloid pathology and associated behavioral deficits in AD mice, an effect associated with enhanced microglial lysosomal activity and Aβ clearance, highlighting its therapeutic potential in AD treatment.
Authors
- Weishan Fu
- Jiaxin Li (ORCID: https://orcid.org/0000-0002-5636-3279)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Yating Wang
- Shihui Guo
- Qi Liu
- Kai Guo
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1002/cns.70807
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00