Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens
Prenatal THC exposure selectively predisposed the female offspring to alcohol vulnerability. The accumbal insight suggests a D2-driven reduced avoidance pathway in the females and a CB1R-driven avoidance behaviour in the males. Over the IA-paradigm, the potentiation in eCB synthesis plays a critical role in excessive alcohol drinking in pTHC offspring of both sexes.
Authors
- Giuseppe Tringali (ORCID: https://orcid.org/0000-0002-1030-9429)
- Gianluca Lavanco (ORCID: https://orcid.org/0000-0002-4962-379X)
- Martina Di Bartolomeo (ORCID: https://orcid.org/0000-0003-4266-7607)
- Petr Palivec (ORCID: https://orcid.org/0000-0003-3729-8712)
- Martin Kuchař (ORCID: https://orcid.org/0000-0002-7616-6352)
- Anna Maria Brancato
- Valentina Castelli
- Carla Cannizzaro
- Claudio D’Addario
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Teramo (IT)
- Agostino Gemelli University Polyclinic (IT)
- Karolinska Institutet (SE)
- Department of Health (ES)
- National Institute of Mental Health (CZ)
- University of Palermo (IT)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1177/02698811261420097
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00