Fcer1g and St3gal1: Macrophage-associated angiogenesis biomarkers and therapeutic targets in sepsis-induced acute lung injury

In mouse in vivo studies, Fcer1g and St3gal1 were shown to precisely mediate intricate macrophage-endothelial cell interactions via glycoimmune signaling pathways at the molecular level. This interaction finely modulates endothelial cell activation and drives angiogenic remodeling, critically impacting SALI progression. Given the physiological and pathological parallels between mice and humans, our findings offer a theoretical underpinning for subsequent human - oriented research. Moving forward, efforts should focus on verifying the expression patterns, action mechanisms, and diagnostic/therapeutic potential of these genes in relation to human SALI - associated signatures.