CRISPR Base Editing Correction of <i>TGFBI</i> Mutations in Autosomal Dominant Corneal Dystrophies
Our study demonstrates the feasibility and safety of CRISPR adenine base editing as a new therapeutic strategy for correcting common TGFBI mutations in corneal dystrophies, paving the way for further preclinical testing.
Authors
- James H. Ellis (ORCID: https://orcid.org/0000-0002-8755-6583)
- William Presley
- Bridget Blevins (ORCID: https://orcid.org/0009-0002-1340-9967)
- Zhonggang Hou (ORCID: https://orcid.org/0000-0002-3676-6724)
- Mason Myers
- Connor W Davison
- Dejuan Kong
- Shahzad I. Mian
- Lev Prasov
- Yan Zhang
- Jue Chen
Institutions
- University of Michigan (US)
- Michigan United (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1167/iovs.67.2.60
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00