Human VH-antibody-based CAR T cells targeting folate receptor-alpha show enhanced persistence and reduced T-cell exhaustion against ovarian cancer
Human FOLR1-V<sub>H</sub> CAR T cells demonstrated potent antitumor activity with reduced exhaustion and enhanced persistence. These properties highlight the V<sub>H</sub> domain as a promising targeting module for next-generation CAR T-cell therapies in ovarian cancer.
Authors
- Koramit Suppipat (ORCID: https://orcid.org/0000-0002-4010-933X)
- Supannikar Tawinwung (ORCID: https://orcid.org/0000-0003-2151-4580)
- Nithidol Sakunrangsit (ORCID: https://orcid.org/0000-0002-1759-5974)
- Kannika Khantasup (ORCID: https://orcid.org/0000-0002-7163-513X)
- Nattiya Hirankarn
- Natapol Pornputtipong
Institutions
- Chulalongkorn University (TH)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1016/j.biopha.2026.119169
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00