Association of Intratumoral Microbiota with Prognosis in Head and Neck Squamous Cell Carcinoma
High intratumoral bacterial load and low diversity are prognostic factors associated with survival in HNSCC, particularly in HPV-negative patients. Incorporating microbiome assessment into risk stratification may enhance prognostic precision and inform microbiota-directed therapeutic approaches.
Authors
- Nicole Kawachi
- Erqiang Hu (ORCID: https://orcid.org/0000-0002-1798-7513)
- Gregory Rosenblatt
- Leti Núñez (ORCID: https://orcid.org/0000-0002-3260-6301)
- Shanye Yin (ORCID: https://orcid.org/0000-0001-9116-5238)
- Jianhong An (ORCID: https://orcid.org/0000-0001-6943-872X)
- Stelby Augustine
- Michael B. Prystowsky (ORCID: https://orcid.org/0000-0002-9548-6917)
- Jeffrey E. Segall (ORCID: https://orcid.org/0000-0001-5425-9315)
- Junpeng Li (ORCID: https://orcid.org/0009-0001-9197-178X)
- Gujie Wu (ORCID: https://orcid.org/0009-0002-6705-0857)
- Wenjun Deng
- Thomas J. Ow
- Amit Verma
- Evan Z. Song
- Richard V. Smith
- Harry Ostrer
- Lin Cheng
- Jing Zhu
Institutions
- Albert Einstein College of Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Montefiore Medical Center (US)
- Amherst College (US)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Tohoku University (JP)
- Massachusetts General Hospital (US)
- Regenerative Medicine Institute (MX)
- Bioinformatics Institute (SG)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-4420
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00