Multi-Omics Analysis of CDKN2A (p16INK4a) in Cervical Carcinoma in the Context of Human Papillomavirus and in Endometrial Carcinoma
CDKN2A exhibits strong diagnostic performance in HPV-associated cervical cancer and moderate, cohort-dependent discriminatory ability in endometrial carcinoma. These findings reinforce its established diagnostic role in CESC and propose adjunctive utility in UCEC, underscoring the importance of tumor-contextual interpretation of CDKN2A expression in gynecologic malignancies.
Authors
- Taghreed Mohamed Osman Derar
- Esra’a Abudouleh
- Rasha Elsayim (ORCID: https://orcid.org/0000-0002-6937-2588)
- Mariam Abdulaziz Alkhateeb (ORCID: https://orcid.org/0000-0001-8019-616X)
- Sami Habiballa Abdalla Mohamed
- Nihal Almuraikhi
- Heba W. Alhamdi
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- King Saud University (SA)
- King Khalid University (SA)
Publication Details
- Journal
- Genes
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3390/genes17030281
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Nourah Bint Abdulrahman University