Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis
In MS patients, lower cerebral SvO<sub>2</sub> (compared with HCs) is statistically associated with microstructural alterations in the NAWM. Our mediation models are consistent with a pathway whereby lower SvO<sub>2</sub> is associated with greater lesion burden and worse functional scores via its association with NAWM damage. These findings support the exploratory value of SvO<sub>2</sub> and NAWM integrity as potential biomarkers for monitoring MS progression, which warrants validation in further longitudinal studies.
Authors
- Yunyun Duan
- Shuang Xia (ORCID: https://orcid.org/0000-0003-1626-6383)
- Ke Lv (ORCID: https://orcid.org/0000-0001-8779-9860)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Chao Chai
- Decai Tian
- Zhizheng Zhuo
- Ai Guo
- Xinli Wang
Institutions
- Capital Medical University (CN)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1002/acn3.70354
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00