Ultra-low Concentrations of Cisplatinum Down to the IC <sub>10</sub> in Combination With Recombinant Methioninase Are Synergistically Effective Against Lung Cancer Cells <i>In Vitro</i> and <i>In Vivo</i>
Methionine restriction enhances the efficacy of ultra-low-dose cisplatinum on lung cancer cells <i>in vitro</i>. Low-dose cisplatinum in combination with an MR diet prevented lung-cancer growth in nude mice. The present approach of cancer therapy may help reduce platinum-related toxicity and improve treatment outcomes, suggesting further investigation for clinical translation.
Authors
- N. Yamamoto
- H. Tsuchiya
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Byung Mo Kang
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- YUTA MIYASHI
- JIN SOO KIM
- YOHEI ASANO
- M. Bouvet
- R. M. Hoffman
- SHINJI MIWA
- KATSUHIRO HAYASHI
- QINGHONG HAN
- SATORU DEMURA
- SHUKUAN LI
- TAKASHI HIGUCHI
- HIROAKI KIMURA
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- In Vivo
- Published
- 2026-02-27
- DOI
- https://doi.org/10.21873/invivo.14238
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00