Oral Administration of Itraconazole Induces M1 Polarization of Tumor-associated Macrophages in Gynecological Cancer
ITZ treatment was associated with increased infiltration of M1-like TAMs in cancer tissues, suggesting an immunomodulatory effect. These findings support further investigation of ITZ as a potential adjunct in cancer therapy.
Authors
- M. Iwamoto (ORCID: https://orcid.org/0009-0004-0318-0120)
- Chisato OHE
- Satoko Mibayashi
- Roze Taniguchi
- Tomoyuki Sasano (ORCID: https://orcid.org/0000-0003-3754-475X)
- Momoko Nakabayashi
- Kazuko Sakata (ORCID: https://orcid.org/0000-0001-6509-216X)
- Hiroshi Tsubamoto (ORCID: https://orcid.org/0000-0002-6135-6313)
- Seiji Mabuchi
- SACHIYO NARITA
- YUMI TAKIMOTO
- TOMOKO UEDA
- YU WAKIMOTO
Institutions
- Hyogo Medical University (JP)
- Hyogo University (JP)
- Kobe College (JP)
Publication Details
- Journal
- In Vivo
- Published
- 2026-02-27
- DOI
- https://doi.org/10.21873/invivo.14237
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology