Identification of additional <i>DPYD</i> polymorphisms that increase the risk of severe fluoropyrimidine toxicity and improved predictive accuracy when combined with previously validated variants
Five uncommon DPYD variants, in combination, increase FP toxicity risk and improve risk prediction. Testing these variants could identify more high-risk patients who should receive adjusted FP doses to prevent severe toxicity.
Authors
- Nam Nguyen-Hoang (ORCID: https://orcid.org/0000-0003-4291-3767)
- Kyoin Koo
- J. T. Kwon
- Faisal Shakeel (ORCID: https://orcid.org/0000-0002-8468-8740)
- Sophia Jaso
- Kelly Nugent
- Amy Pasternak
- D. L. Hertz
Institutions
- University of Michigan (US)
- Michigan Medicine (US)
- Ann Arbor Center for Independent Living (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-4721
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00