Serum vitamin D and lean non-alcoholic fatty liver disease: a nonlinear ‘L-shaped’ association in a national cross-sectional study
This large-scale study is the first to identify a significant 'L-shaped' nonlinear association between serum vitamin D and lean NAFLD, wherein the association is most potent at concentrations below approximately 60 nmol/L. This finding highlights an epidemiological inflection point and underscores the need for nonlinear approaches in future research.
Authors
- Chongxiao Li (ORCID: https://orcid.org/0009-0004-2215-4892)
- Jingbo Wang (ORCID: https://orcid.org/0000-0002-4961-0921)
- Erzhuo Xia
- Gang Ma
- Ying Han
Institutions
- Chinese People 's Liberation Army No. 85 Hospital (CN)
- Xijing Hospital (CN)
- Chinese People’s Liberation Army 263 hospital (CN)
- U.S. Air Force Institute of Technology (US)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1080/07853890.2026.2634463
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00