Exosomal circZNF638 promotes postmenopausal osteoporosis progression through MGAT1-mediated SMAD9 glycosylation

The findings of this study indicate that exosomal circZNF638 derived from osteoclasts plays a pivotal role in promoting the progression of POMP through the MGAT1-mediated N-glycosylation of SMAD9. These insights provide a deeper understanding of the molecular mechanisms underlying POMP.

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Publication Details

Journal
Connective Tissue Research
Published
2026-02-26
DOI
https://doi.org/10.1080/03008207.2026.2626749
Primary Topic
Circular RNAs in diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Exosomal circZNF638 promotes postmenopausal osteoporosis progression through MGAT1-mediated SMAD9 glycosylation

Xin Fang, Shangben Lin, J Li, Yuxiao Luo et al.
Connective Tissue Research
Circular RNAs in diseases
article

Exosomal circZNF638 promotes postmenopausal osteoporosis progression through MGAT1-mediated SMAD9 glycosylation

Xin Fang, Shangben Lin, J Li, Yuxiao Luo, Yingjie Qi
article en

Abstract

The findings of this study indicate that exosomal circZNF638 derived from osteoclasts plays a pivotal role in promoting the progression of POMP through the MGAT1-mediated N-glycosylation of SMAD9. These insights provide a deeper understanding of the molecular mechanisms underlying POMP.

Connective Tissue Research
Affiliated Hospital of Hangzhou Normal University (CN)
Openalex Percentile: Top 40%
Circular RNAs in diseases
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