Longitudinal MRI study of hippocampal subfields Morphometry in early Parkinson's disease
These findings suggest that, in this cohort, shape analysis may capture baseline subfield differences that are not apparent using volumetric measures in early-stage PD. This study suggests hippocampal subfield shape analysis may help characterize early structural differences related to cognition in PD. The left fimbria warrants further study as a candidate imaging marker of cognitive vulnerability in PD.
Authors
- Ling Ling Chan (ORCID: https://orcid.org/0000-0001-7603-7334)
- Thomas Welton (ORCID: https://orcid.org/0000-0002-9503-2093)
- Dede Liana Heng (ORCID: https://orcid.org/0009-0007-2188-4705)
- Xinyi Choi
- Thomas Wei Jun Teo (ORCID: https://orcid.org/0009-0006-7518-677X)
- Eng King Tan
- Kay Yaw Tay
- Zheyu Xu
- Louis Chew-Seng Tan
- Shermyn Neo
- Samuel Yong-Ern Ng
- Tingyu Wu
- Wing Lok Au
Institutions
- Singapore General Hospital (SG)
- Duke-NUS Medical School (SG)
- National Neuroscience Institute (SG)
- National University Hospital (SG)
Publication Details
- Journal
- Parkinsonism & Related Disorders
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1016/j.parkreldis.2026.108259
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- National Medical Research Council