Clinical Complete Response and Organ Preservation Strategies in Rectal Cancer: A Real-World Single-Center Experience Clinical Complete Response and Organ Preservation in Rectal Cancer
In this real-world cohort, baseline tumor size and clinical stage were the main determinants of clinical complete response and eligibility for organ-preservation strategies in rectal cancer. Small tumors (<4 cm) showed high response rates regardless of neoadjuvant regimen. These findings support response-adapted, individualized treatment strategies and highlight the importance of tumor burden in selecting candidates for non-operative management in routine clinical practice.
Authors
- Quiteria López Hernández
- Miguel Ruiz Marín (ORCID: https://orcid.org/0000-0003-2243-4750)
- Eduardo Ortiz (ORCID: https://orcid.org/0009-0003-3753-4401)
- Guillermo Carbonell (ORCID: https://orcid.org/0000-0001-6780-6883)
- C F Manso
- Israel Abellán
- Noelia Ibáñez
- Jesús Abrisqueta
- L. Frutos
- A. Ono
- I. De la Fuente
- Y. Bautista
- G. Marín-Zafra
- M. Guirao
- P. Ruiz
- J. L. Alonso-Romero
- J. A. Nadal
- M. Sánchez
- J. A. Encarnación
- C. Rodríguez
- M. Montoya
- M. Royo-Villanova
- S. González
- B. Quiles
Institutions
- Universidad Politécnica de Cartagena (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Cancers
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3390/cancers18050763
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00