Effect of Autologous Bioactive Concentrated Growth Factor and Residual Dental Pulp on Dentin–Pulp Complex Regeneration

<b>Background/Objectives:</b> This study aimed to evaluate the regenerative potential of autologous concentrated growth factor (CGF) combined with residual pulp tissue in immature dog teeth using a histological and histomorphometric analysis. <b>Materials and Methods:</b> Thirty immature anterior and premolar teeth, harvested from four dogs, were randomly assigned to three groups (<i>n</i> = 10 each): group I (negative control, untreated teeth), group II (positive control, complete pulp removal with blood clot in the canal), and group III (experimental, partial pulp removal with 1-4 mm residual pulp and placement of autologous CGF). After 1 and 3 months, animals were euthanized, and samples were processed for histological and histomorphometric assessments. <b>Results</b>: The CGF-treated group exhibited newly formed tissue with morphological characteristics comparable to the negative control group after partial pulp removal. <b>Conclusions</b>: The combination of CGF with 1-4 mm of residual pulp was associated with enhanced tissue organization, representing a promising approach for dentin-pulp complex (DPC) regeneration within this experimental context.