Quantification of the Human Satellite 2 (HSAT2) Repeat in the Plasma Cell-Free DNA of Patients with Colon Cancer
To our knowledge, this is the first study to conduct a hybridization capture assay using a biotinylated probe as a feasible approach for targeted enrichment of cfDNA from plasma. Our results confirm the outcomes of our recent article based on targeted sequencing and reveal that some specific HSAT2 sequences may exhibit increased cancer abundance.
Authors
- Cemil Burak Kulle (ORCID: https://orcid.org/0000-0003-2956-4486)
- Ebru Esin Yörüker (ORCID: https://orcid.org/0000-0002-2809-5975)
- Abel J. Bronkhorst (ORCID: https://orcid.org/0000-0003-4809-8900)
- Uğur Gezer (ORCID: https://orcid.org/0000-0001-6752-7526)
- Stefan Holdenrieder
- Betül Aksu
- Emre Özgür
- Ilgin Gökçe Demir
Institutions
- Deutsches Herzzentrum München (DE)
- Istanbul University (TR)
Publication Details
- Journal
- Current Issues in Molecular Biology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3390/cimb48030256
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00