Dynamic TyG trajectories cumulative TyG burden are associated with in-hospital mortality in acute brain injury: a multicenter interpretable machine-learning analysis

In ICU-treated ABI, TyG is better modeled as a time-aware exposure: trajectory differences become prognostically relevant only after the first week, whereas cumulative TBM8p7 shows a graded, independent association with mortality. Both metrics add risk information beyond conventional severity indicators and can be integrated into an interpretable, externally tested model.