Neurobehavioral correlates of inhibitory control in youth at-risk for early low-level alcohol use initiation: neuroimaging findings from the ABCD study

This study demonstrates a possible role of neural correlates of inhibitory control that are associated with substance use initiation. Despite behavioral similarities, the study detects differential neural markers of inhibitory control between AE and AN youth, an effect potentially driven by impulsive personality trait markers. As these markers could be both constitutionally and environmentally based, our results suggest that early substance use is accompanied by detectable differences in brain activation in key regions, which may be similar to those in later stages of use, highlighting the importance of delaying the age of alcohol onset.