E3 ubiquitin ligase SKP2 limits autophagosome formation during Staphylococcus aureus infection
These findings underscore that SKP2 is an important regulator of autophagosome formation, preventing excessive autophagy from being exploited by <i>S. aureus</i>. In conclusion, our findings reveal novel molecular mechanisms involved in the interaction between host cells and <i>S. aureus</i> providing potential approaches for targeted therapeutic intervention.
Authors
- Clemens Cammann (ORCID: https://orcid.org/0009-0008-1699-0607)
- Eylin Topfstedt
- Silva Holtfreter (ORCID: https://orcid.org/0000-0002-2672-8230)
- Ulrike Seifert (ORCID: https://orcid.org/0000-0003-1037-3487)
- Kristin Surmann (ORCID: https://orcid.org/0009-0009-7305-3457)
- Abhishek Kumar Singh (ORCID: https://orcid.org/0000-0002-4523-6055)
- Leif Steil (ORCID: https://orcid.org/0000-0002-0733-8421)
- Barbara M. Bröker (ORCID: https://orcid.org/0000-0002-5020-8542)
- Uwe Voelker
- Madina Baglanova
- Michael Lammers
- Karsten Becker
Institutions
- Friedrich-Loeffler-Institut (DE)
- Universitätsmedizin Greifswald (DE)
- Universität Greifswald (DE)
- Institute of Immunology (HR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fcimb.2026.1749151
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00