Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming
These findings suggest that BRU targets metabolic plasticity in TNBC cells, highlighting its potential as an adjuvant therapy to enhance anti-tumor efficacy while reducing chemotherapy-associated toxicity.
Authors
- Edwin Cheung (ORCID: https://orcid.org/0000-0001-8034-2833)
- Maoxuan Liu (ORCID: https://orcid.org/0000-0002-0953-9673)
- Xuan Yu (ORCID: https://orcid.org/0000-0003-2193-4761)
- Cindy Wu
- Liang Chen
- Xueling Diao
- Xiaokai Fan
- Siyuan Wang
Institutions
- Sun Yat-sen University (CN)
- University of Macau (MO)
- Fudan University (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Sun Yat-sen University Cancer Center (CN)
- Shenzhen Technology University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fonc.2026.1708878
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00