Acetaminophen-Induced Type II Kounis Syndrome: A Case Report Highlighting Diagnostic Challenges and the Utility of a Physician-Staffed Rapid Response Car

Kounis syndrome (KS) is a clinical condition where anaphylaxis induces acute coronary syndrome. This report describes a case of Type II KS in an 85-year-old male, triggered by intravenous acetaminophen, resulting in total occlusion of the right coronary artery. The intervention of a physician-staffed rapid response car (RRC) facilitated early pre-hospital diagnosis of ST-segment elevation myocardial infarction (STEMI). This enabled an integrated transition to emergency percutaneous coronary intervention (PCI). The case demonstrates the utility of advanced pre-hospital systems in managing the therapeutic conflicts associated with KS.

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Publication Details

Journal
Cureus
Published
2026-02-26
DOI
https://doi.org/10.7759/cureus.104346
Primary Topic
Food Allergy and Anaphylaxis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Acetaminophen-Induced Type II Kounis Syndrome: A Case Report Highlighting Diagnostic Challenges and the Utility of a Physician-Staffed Rapid Response Car

Satoshi Hashiguchi
Cureus
Food Allergy and Anaphylaxis Research
article

Acetaminophen-Induced Type II Kounis Syndrome: A Case Report Highlighting Diagnostic Challenges and the Utility of a Physician-Staffed Rapid Response Car

Satoshi Hashiguchi
article en

Abstract

Kounis syndrome (KS) is a clinical condition where anaphylaxis induces acute coronary syndrome. This report describes a case of Type II KS in an 85-year-old male, triggered by intravenous acetaminophen, resulting in total occlusion of the right coronary artery. The intervention of a physician-staffed rapid response car (RRC) facilitated early pre-hospital diagnosis of ST-segment elevation myocardial infarction (STEMI). This enabled an integrated transition to emergency percutaneous coronary intervention (PCI). The case demonstrates the utility of advanced pre-hospital systems in managing the therapeutic conflicts associated with KS.

Cureus
Good health and well-being
Openalex Percentile: Top 35%
Food Allergy and Anaphylaxis Research
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