Integrated Computational Analysis Reveals Structurally Destabilizing Missense Variants in the PDX1 Transcription Factor
These findings will provide insight into the molecular mechanisms by which PDX1 mutations may contribute to β-cell dysfunction and diabetes development and offer a rational framework for prior-itizing variants for experimental validation and clinical interpretation.
Authors
- Elsadig Mohamed Ahmed (ORCID: https://orcid.org/0000-0002-5027-7206)
Institutions
- University of Bisha (SA)
Publication Details
- Journal
- Genes
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3390/genes17030273
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bisha