Deciphering immune heterogeneity in lung adenocarcinoma via machine learning-based Differential Phenotype Immune Score: TPX2 as a key biomarker for immunotherapy resistance
This study identifies a proliferation-driven immune suppression program in LUAD, establishes DPIS as a robust and clinically applicable framework for immune stratification, and highlights TPX2 as a potential therapeutic target for overcoming immune resistance.
Authors
- Kaisheng Yuan (ORCID: https://orcid.org/0000-0002-0768-9512)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Hong Xin (ORCID: https://orcid.org/0000-0002-7235-0056)
- Yifan Ma (ORCID: https://orcid.org/0000-0001-6962-8582)
- Ying Xing
- Yi Dong
- Siyi Sun
- Xin Wang
- Ying Cao
- Man Dou
Institutions
- Harbin Medical University (CN)
- Ministry of Education (SA)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Washington State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fimmu.2026.1797282
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00