Can Infections Drive Frailty? Insights from the Baltimore Longitudinal Study of Aging

A history of infections may accelerate the rate of frailty progression, defined as the transition from robustness to pre-frailty/frailty, and has an independent effect with frailty on increasing the risk of death. The mediating role of Leptin suggests that obesity may be implicated in the relationship between history of infections and frailty.

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Publication Details

Journal
The Journals of Gerontology Series A
Published
2026-02-23
DOI
https://doi.org/10.1093/gerona/glag043
Primary Topic
Frailty in Older Adults
Type
article
Field-Weighted Citation Impact
0.00
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article

Can Infections Drive Frailty? Insights from the Baltimore Longitudinal Study of Aging

Mario Barbagallo, Toshiko Tanaka, Keenan A Walker, Ligia J Dominguez et al.
The Journals of Gerontology Series A
Frailty in Older Adults
article

Can Infections Drive Frailty? Insights from the Baltimore Longitudinal Study of Aging

Mario Barbagallo, Toshiko Tanaka, Keenan A Walker, Ligia J Dominguez, Michael R Duggan, Francesco Saverio Ragusa, Luigi Ferrucci, Nicola Veronese
article en

Abstract

A history of infections may accelerate the rate of frailty progression, defined as the transition from robustness to pre-frailty/frailty, and has an independent effect with frailty on increasing the risk of death. The mediating role of Leptin suggests that obesity may be implicated in the relationship between history of infections and frailty.

The Journals of Gerontology Series A
Università degli Studi di Enna Kore (IT), Saint Camillus International University of Health and Medical Sciences (IT), Institute on Aging (US), National Institute on Aging (US), University of Palermo (AR), University of Palermo (IT)
Good health and well-being
Openalex Percentile: Top 40%
Frailty in Older Adults
DOISourceOpenAlex
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